Factors Causing Alzheimer’s Disease

Many scientists don’t yet entirely discern what causes Alzheimer's disorder, but it has become increasingly understandable that it develops because of several events happening i n succession that make a place in the brain. Dr. Michael Mullan, (CEO) Roskamp Institute, Florida has devoted a lifetime searching for the cause of this disease. As per him, the cause is a mixture of environmental, genetic and lifestyle factors. Because people’s standard of living differs, the probability of any one of these factors in increasing or decreasing the hazard of developing Alzheimer's differs from one to one.

The abnormal protein bunches, inclusions, in the brain tissue are always associated with the disease, but there could be another underlying process that is actually causing the Alzheimer's - scientists are not yet certain.

This disorder has three stages:

• Preclinical
• Mild cognitive impairment
• Dementia.

Changes In The Brain

One of the bulky mysteries of Alzheimer’s disorder is why it largely strikes older adults. Study on how the brain changes normally with age is shedding medium of vision on this interrogation. For example, scientists are acquisition of knowledge how age-of the same nature changes in the brain may disadvantage neurons and grant or bestow (as a share) to Alzheimer’s injury.

Role Of Genetics

The more researchers learn about this disorder, the more they analyze that genes play a crucial role in its development. As per London based Roskamp Institute, Alzheimer is a rare sort of disorder. It occurs to people at an age of 30 to 60 and represents less than 5 percent of all the people who have this disorder. Most cases of attack by this disease are changes in one of three known genes inherited from a father or mother.

Most people with this disorder have “late-onset” Alzheimer’s, which normally comes into action after people cross 60. Many studies have linked the apolipoprotein E (APOE) gene to slow-attack Alzheimer’s. One of them, APOE ε4, increases the person’s probability of getting the disorder. However, carrying the APOE ε4 cast of the gene does not actually mean that it will definitely cause the dementia. Also, a probability still remains that people without APOE ε4 may get this disease. Most experts believe that more genes may contribute to the occurrence of slow-attack Alzheimer’s. Scientists around the world are seeking for these genes, and have discovered a variety of genes that may be contributors to the occurrence of this disease.

Women More Prone To Alzheimer

Many, but not all, studies have found that women have a higher danger for Alzheimer's disorder than men. It is certainly clear that women live longer as compared to men, but age alone does not seem to unfold the increased frequent disease occurrence in women. The frequent occurrences of Alzheimer’s distemper in women have led to consideration about the role of estrogen in Alzheimer's disease.

Other Factors

Factors including diabetes, high blood pressure and high cholesterol increase the risk of stroke, which can lead to another type of disorder. Low education is also one of the reasons.

Michael Mullan, The World's Leading Neuroscientist

A lot of research has been going on in the field of Alzheimer's and brain development. And, one of the leading institutes doing this research is Roskamp Institute. Based out of Sarasota in United States, is an non-profit organization, which is committed towards discovering and treating neuropsychiatric as well as neuro-degenerative disorders.

Michael Mullan happens to be the director of this prestigious institute. Dr. Mullan was born in 1956 in Kent. He did his graduation in Medicine and Surgery from London University. He did his post-graduation in Psychiatry from Royal college in 1990. Then, he did his PhD in Philosophy, specializing in Molecular Genetics from London University, in the year 1993.

Career of Dr. Mullan:
Michael began his career in the year 1988 and worked for 3 years in a major teaching hospital in London named The Royal Free Hospital. Then, he worked as senior registrar with the Psychiatric hospital named Friern Hospital. He has also worked as Professor for Biological Psychiatry, and professor in Department of Neurology and Pathology. He is the CEO of Roskamp-Institute in Florida currently. He has been the main person behind the research on Alzheimer's disease. He holds around 12 patents in total. And, he has published about 200 scientific studies in the past 3 decades. And, all these published materials are on Alzheimer's disease, neuropathy of dementia, molecular genetics, manic-depression, alcoholism, schizophrenia, etc. He has received a number of awards and honours for all his research work.

Dr. Mullan is the bio-medical researcher of Beta Amyloid Protein. And, he has been working on its relation with Alzheimer's disease. His research is quite well known in the bio-medical community. Due to his research, Swiss Mutation has been identified. The transgenic animals for the Alzheimer's makes use of the Swedish Mutation. The institute, which is headed by Dr. Mullan and Dr. Fiona Crawford, has been dedicated towards the research. The institute has various experienced scientists, technicians and the most-updated equipment and tools for conducting the scientific research. And, the research quality is also the best. As per them, better science leads to a real discovery. The mission of this institute is conducting the scientific research so that safer and more effective drugs can be taken out for treating the mind-related diseases. 

The Roskamp institute in Sarasota has a wide range of technical innovative advancements. And, under the leadership of Dr. Mullan, there are about 70 clinicians, scientists, students, and other administrative staff, who work together for pursuing the research so that the source of the neurological disorders can be found out. And, once the cause is found out, the future treatments can be devised. The institute is dedicated towards discovering safe and effective drug therapies. With the help of these therapies, the aging can happen in an healthy manner.

With the efforts of Dr. Mullan, the Neuroscientist, there has been a lot of work towards improvement of the diagnosis of Alzheimer's patients. So, anybody, who is suffering from a disease of the mind, can find the appropriate help and guidance from here.

Alzheimer – Memory Loss that can Lead to Death

Alzheimer is a disease which has surfaced more during the recent years. It is caused by the protein compounds that are accumulated in the brain. Since it is a neuro-degenerative disease, the person gets worse as time passes by. The disease is recognized by the early onset of short term memory loss. This can lead to death as the functions of the body are lost one at a time.

There are many medical institutes that are researching on the Alzheimer’s disease. The researchers believe that it is mostly caused by genetic disorder. Michael Mullan is one of the most popular researchers who studied the cause and cure of Alzheimer. He is well trained in molecular genetics to perform gene research with respect to the disease. He currently holds the position of President and CEO in Roskamp Institute which is located in Florida. Dr.Mullan made ground breaking research and presented over 200 articles on Alzheimer which also includes the treatment for the disease.

Dr. Mullan having experience of more than 20 years in biotechnology, invented patents that used APP mutations. He worked for the causes of this disease along with its cure by receiving grants from federal organizations. He was the first person to identify the genetic cause of the disease. It was established that people with gene mutations present in TREM2 had a higher risk of getting affected by the Alzheimer disease.

There are medications which can help in treating the patients and can slow down the progress of Alzheimer, but a sure cure for the disease is still a work under progress. Roskamp is the closest institute which is on the way to finding a cure. The drug, Nilvadipine, was administered for treating hypertension, which is identified as one of the reasons that cause the disease. This drug has been proved to stop the protein production in the brain. Amyloid is considered to be a tombstone and hence the drug was developed to stop its production all together.

Michael Mullan Roskamp Institute diagnoses patients with Alzheimer and offer clinical trial for the drug which was developed. Observations were made in the genes and the medical history of the relatives in order to diagnose the disease. Medical imaging like MRI and PET are used to rule out other forms of dementia. This type of diagnosis can be made only after the onset of the disease. Early diagnosis include cerebrospinal fluid test for the presence of amyloid. This spinal tap predicts the onset of the disease which is about 94% accurate. 

There is no drug at present to prevent the onset of this disease. But, various studies prove that measures like dieting, intellectual activities and reducing cholesterol level can be done to decrease the chance of being affected by Alzheimer’s disease.

Understanding the Possibilities of Curing Alzheimer Disease

Medical Treatment

It is a fact that presently, there exists no medicine for treating Alzheimer disease. At the same time, it is not possible to prevent the disease or have effective treatments for it. However, there are present few non-drug and drug treatments, which do provide relief on a temporary basis for both cognitive and behavioral symptoms.

Cholinesterase Inhibitors

These are known to assist in preserving the capability of the sick nerve endings for transmitting nerve messages to next cell present in chain.

Neurotransmitter Acetylcholine

In regards to this disease, one of the most vital neurotransmitter is said to be acetylcholine (which is actually a very small blip of chemical that diffuses quite rapidly across junctions of the nerve cell for stimulating the next cell), which is utilized by nerve cells in brain part to think and for memory making. At the same time, it is equally essential that acetylcholine gets eliminated at the earliest after the message has been carried across junction. In case, it is not, then it is likely to keep on stimulating downstream cell. It can be disastrous, while leading to possible attacks.

Disturbance in Degradation Process

Generally, acetylcholine gets destroyed instantly after delivering the message by an enzyme known as cholinesterase. In Alzheimer’s, nerve cell endings could get much sicker and acetylcholine amount that is produced by every nerve impulse could get lesser and lesser with the progress of the disease.

What does Cholinesterase Inhibitors do?

Cholinesterase inhibitors which are utilized as Alzheimer’s cure might restrain destroying by cholinesterase of acetylcholine, which results in acetylcholine level getting high enough for getting the message over the next cell.

Temporary Solution

However, this would not work forever. Over a period of time, sick nerve endings tend to start degenerating and withdrawing from junctions. The messages not longer could be transferred. Generally, it takes around 2 to 3 years before the situation gets reached (occasionally it tends to last much longer). It explains as to why cholinesterase inhibitors generally work on a temporary basis.

Researching on Treatment of the Disease

Scientists at Sarasota camp are continuing with the research for coming up with treatments that are effective and for holding the disease off, quickly. By researching on the web, one can get few examples. Article regards to Nature Genetics does mention identification of more five genes behind this disease by a research consortium.

The experts at Michael Mullan have been trying to come up with researches for understanding the events which leads towards damage of bigger brain parts and eventually complete loss of the cognitive abilities. According to a published article in a leading Journal, insulin can have a new, powerful role to fight the disease. The article describes new clinical researches done by the experts that found that low insulin dose is found to suppress successfully the expression in blood of 4 precursor proteins that are involve in pathogenesis of the disease.

The roskamp institute states that it has been working on to come up with novel cures having the capability to slow down the progression rate of the disease and try to eradicate it in the near future.

For More Details Visit Here: Michael Mullan

MICHAEL MULLAN AND HIS ALZHEIMER’S RESEARCH AT FLORIDA

All about the Great Researcher

Biomedical researcher Michael Mullan has conducted Alzheimer’s disease which was based on the identification of the Swedish Mutation which is present in the familial form. This person is trained in England as a physician and received his medical degree in 1995 and PhD in molecular genetics from London University. Currently he is working as a CEO and the president of the Roskamp Institute. He has published more than 200 papers.

He had conducted the important medical research in neurodegenerative disorders. He is a very experienced person and is also imparting knowledge on the subject dementia. He is working in research centers and medical institutions too.

Fighting Alzheimer’s Disease

It was a very great study by him at Roskamp Institute at Sarasota Florida in which he discovered that that all the disorders which are genetic are found to be in amyloidal genes. The whole of this research was basically based on the Amyloid and now is categorized as a very important part of the Alzheimer’s disease. It is also found that this disease is commonly found at the ages of 50 to 70. All the studies which were conducted followed by a result that the small protein amyloid when accumulates can contribute to the series of things which can lead to cognitive declination and degeneration.

The research was going-on on mice which had the errors in it like a human who is on the early stage of the disorder called Alzheimer. This study on the mice  has gave the researchers an idea about how a small protein called amyloid can cause disorder  and can lead to the death of neurons. Many of the pharmaceutical labs and academic labs have this kind of mice. So they used to test many such drugs on the mice which can prevent them from this disease. Just to give a solution to this problem, many researches were conducted. This disease actually came from a family of a woman Carol Jennings from England. Her family had this genetic problem in which fifty percent that is half of the off springs who used to take birth in their family were having this disease at an early stage. And then she started for the search of the people who were interested to carry on the research on Alzheimer’s disease. By doing this she not only helped her family but also helped the people who were suffering from this disease.

At all the positions on which Michael Mullan worked, he made efforts to research on the cure of neurodegenerative disorders for the long-term.

The Roskamp institute at which he worked was always working on the fact that they wanted to understand the causes and the perfect cures for neuropsychiatric and neurodegenerative disorders and the kind of addictions that happens due to that. This institute had utilized all the range of scientific and technological approaches, so that they can understand its causes and the kind of various therapies for curing this disorder with the emphasis laid on the Alzheimer’s disease.

For More Details Visit Here: -- Michael Mullan Roskamp