Factors Causing Alzheimer’s Disease

Many scientists don’t yet entirely discern what causes Alzheimer's disorder, but it has become increasingly understandable that it develops because of several events happening i n succession that make a place in the brain. Dr. Michael Mullan, (CEO) Roskamp Institute, Florida has devoted a lifetime searching for the cause of this disease. As per him, the cause is a mixture of environmental, genetic and lifestyle factors. Because people’s standard of living differs, the probability of any one of these factors in increasing or decreasing the hazard of developing Alzheimer's differs from one to one.

The abnormal protein bunches, inclusions, in the brain tissue are always associated with the disease, but there could be another underlying process that is actually causing the Alzheimer's - scientists are not yet certain.

This disorder has three stages:

• Preclinical
• Mild cognitive impairment
• Dementia.

Changes In The Brain

One of the bulky mysteries of Alzheimer’s disorder is why it largely strikes older adults. Study on how the brain changes normally with age is shedding medium of vision on this interrogation. For example, scientists are acquisition of knowledge how age-of the same nature changes in the brain may disadvantage neurons and grant or bestow (as a share) to Alzheimer’s injury.

Role Of Genetics

The more researchers learn about this disorder, the more they analyze that genes play a crucial role in its development. As per London based Roskamp Institute, Alzheimer is a rare sort of disorder. It occurs to people at an age of 30 to 60 and represents less than 5 percent of all the people who have this disorder. Most cases of attack by this disease are changes in one of three known genes inherited from a father or mother.

Most people with this disorder have “late-onset” Alzheimer’s, which normally comes into action after people cross 60. Many studies have linked the apolipoprotein E (APOE) gene to slow-attack Alzheimer’s. One of them, APOE ε4, increases the person’s probability of getting the disorder. However, carrying the APOE ε4 cast of the gene does not actually mean that it will definitely cause the dementia. Also, a probability still remains that people without APOE ε4 may get this disease. Most experts believe that more genes may contribute to the occurrence of slow-attack Alzheimer’s. Scientists around the world are seeking for these genes, and have discovered a variety of genes that may be contributors to the occurrence of this disease.

Women More Prone To Alzheimer

Many, but not all, studies have found that women have a higher danger for Alzheimer's disorder than men. It is certainly clear that women live longer as compared to men, but age alone does not seem to unfold the increased frequent disease occurrence in women. The frequent occurrences of Alzheimer’s distemper in women have led to consideration about the role of estrogen in Alzheimer's disease.

Other Factors

Factors including diabetes, high blood pressure and high cholesterol increase the risk of stroke, which can lead to another type of disorder. Low education is also one of the reasons.

Roskamp Institute – Attempting Alzheimer through Objective Researches

Health is a gift for the mind, body and soul and is the true wealth to cherish. However, this gifted wealth often gets aberrated due to disease conditions. If the person is lucky enough, then he can get cured with the available line of drugs; however, there are certain illnesses, the cures for which have remained elusive after long and dedicated researches.

Alzheimer disease is characterized by most of the dementia symptoms such as the memory degradation, visual losses, locomotor losses and identification problems among others. The pitiful aspect of Alzheimer is that most of the symptoms and manifestations are sidelined as that of old age in a very commonly accepted norm, thus leaving the aged person to struggle. The more educated and aware societies of the world have shown greater rates of diagnosis, if not the incidence.

Finding out the fundamental factors

The med community has been engaged in quality and deeper researches so as to establish the reasons, but the cure is still far away. There have been some authentic insight, of course, from some noted quarters like the Roskamp Institute of US. This not for profit research institute has under the inspiring leadership of Michael Mullan produced valuable leads as for understanding some correlations between Alzheimer and associated factors.

Dr Mullan is considered a global authority on Alzheimer research because of his pioneering studies that helped establish the role of beta amyloid protein which he found is overproduced due to a genetic inconsistency. Greater the production of this protein, greater would be the progression rate of the disease.

 Running associated programs for holistic research

Michael Mullan is the CEO of Sarasota based Roskamp Institute and has been guiding the next phase of the researches to bring out more insights through dedicated programs of direct consonances. The institute runs its ‘Vision Research Program’ that is oriented towards studying the visual impairments in the dementia and Alzheimer by studying the patterns of visual cortex and optical nerves over the time in the Alzheimer patients.

The Institute also runs Memory Clinics where objective counseling is offered with the aim of arresting the disease progression. The Roskamp Institute also studies the effect of the potential risk factors as for Alzheimer disease such as the head injuries, family history, depression and hypertension among others. Such correlations have proved to be beneficial as for prescribing the care suggestions for the person where already the onset has been diagnosed.

Carrying out effective yet ethical clinical trials -

The research maneuvers of the Institute are complemented by the ‘Clinical Trials Division’ of it which is an attempt to collect the most authentic of the databases from the willing volunteers in an ethical manner. The volunteers are offered potential cures free of cost together with effective cushioning against the side effects.

 Michael Mullan has established some of the finest standards in this Sarasota institute which is escorting the care and cure attempts with the best of the Biomedical Researcher community at its end. The findings of this Institute have been validated by noted journals that demonstrate the efficacies.

Michael Mullan, The World's Leading Neuroscientist

A lot of research has been going on in the field of Alzheimer's and brain development. And, one of the leading institutes doing this research is Roskamp Institute. Based out of Sarasota in United States, is an non-profit organization, which is committed towards discovering and treating neuropsychiatric as well as neuro-degenerative disorders.

Michael Mullan happens to be the director of this prestigious institute. Dr. Mullan was born in 1956 in Kent. He did his graduation in Medicine and Surgery from London University. He did his post-graduation in Psychiatry from Royal college in 1990. Then, he did his PhD in Philosophy, specializing in Molecular Genetics from London University, in the year 1993.

Career of Dr. Mullan:
Michael began his career in the year 1988 and worked for 3 years in a major teaching hospital in London named The Royal Free Hospital. Then, he worked as senior registrar with the Psychiatric hospital named Friern Hospital. He has also worked as Professor for Biological Psychiatry, and professor in Department of Neurology and Pathology. He is the CEO of Roskamp-Institute in Florida currently. He has been the main person behind the research on Alzheimer's disease. He holds around 12 patents in total. And, he has published about 200 scientific studies in the past 3 decades. And, all these published materials are on Alzheimer's disease, neuropathy of dementia, molecular genetics, manic-depression, alcoholism, schizophrenia, etc. He has received a number of awards and honours for all his research work.

Dr. Mullan is the bio-medical researcher of Beta Amyloid Protein. And, he has been working on its relation with Alzheimer's disease. His research is quite well known in the bio-medical community. Due to his research, Swiss Mutation has been identified. The transgenic animals for the Alzheimer's makes use of the Swedish Mutation. The institute, which is headed by Dr. Mullan and Dr. Fiona Crawford, has been dedicated towards the research. The institute has various experienced scientists, technicians and the most-updated equipment and tools for conducting the scientific research. And, the research quality is also the best. As per them, better science leads to a real discovery. The mission of this institute is conducting the scientific research so that safer and more effective drugs can be taken out for treating the mind-related diseases. 

The Roskamp institute in Sarasota has a wide range of technical innovative advancements. And, under the leadership of Dr. Mullan, there are about 70 clinicians, scientists, students, and other administrative staff, who work together for pursuing the research so that the source of the neurological disorders can be found out. And, once the cause is found out, the future treatments can be devised. The institute is dedicated towards discovering safe and effective drug therapies. With the help of these therapies, the aging can happen in an healthy manner.

With the efforts of Dr. Mullan, the Neuroscientist, there has been a lot of work towards improvement of the diagnosis of Alzheimer's patients. So, anybody, who is suffering from a disease of the mind, can find the appropriate help and guidance from here.

Alzheimer – Memory Loss that can Lead to Death

Alzheimer is a disease which has surfaced more during the recent years. It is caused by the protein compounds that are accumulated in the brain. Since it is a neuro-degenerative disease, the person gets worse as time passes by. The disease is recognized by the early onset of short term memory loss. This can lead to death as the functions of the body are lost one at a time.

There are many medical institutes that are researching on the Alzheimer’s disease. The researchers believe that it is mostly caused by genetic disorder. Michael Mullan is one of the most popular researchers who studied the cause and cure of Alzheimer. He is well trained in molecular genetics to perform gene research with respect to the disease. He currently holds the position of President and CEO in Roskamp Institute which is located in Florida. Dr.Mullan made ground breaking research and presented over 200 articles on Alzheimer which also includes the treatment for the disease.

Dr. Mullan having experience of more than 20 years in biotechnology, invented patents that used APP mutations. He worked for the causes of this disease along with its cure by receiving grants from federal organizations. He was the first person to identify the genetic cause of the disease. It was established that people with gene mutations present in TREM2 had a higher risk of getting affected by the Alzheimer disease.

There are medications which can help in treating the patients and can slow down the progress of Alzheimer, but a sure cure for the disease is still a work under progress. Roskamp is the closest institute which is on the way to finding a cure. The drug, Nilvadipine, was administered for treating hypertension, which is identified as one of the reasons that cause the disease. This drug has been proved to stop the protein production in the brain. Amyloid is considered to be a tombstone and hence the drug was developed to stop its production all together.

Michael Mullan Roskamp Institute diagnoses patients with Alzheimer and offer clinical trial for the drug which was developed. Observations were made in the genes and the medical history of the relatives in order to diagnose the disease. Medical imaging like MRI and PET are used to rule out other forms of dementia. This type of diagnosis can be made only after the onset of the disease. Early diagnosis include cerebrospinal fluid test for the presence of amyloid. This spinal tap predicts the onset of the disease which is about 94% accurate. 

There is no drug at present to prevent the onset of this disease. But, various studies prove that measures like dieting, intellectual activities and reducing cholesterol level can be done to decrease the chance of being affected by Alzheimer’s disease.