Medical Treatment
It is a fact that
presently, there exists no medicine for treating Alzheimer disease. At the same time, it is not possible to prevent
the disease or have effective treatments for it. However, there are present few
non-drug and drug treatments, which do provide relief on a temporary basis for
both cognitive and behavioral symptoms.
Cholinesterase
Inhibitors
These are known to
assist in preserving the capability of the sick nerve endings for transmitting nerve
messages to next cell present in chain.
Neurotransmitter Acetylcholine
In regards to this
disease, one of the most vital neurotransmitter is said to be acetylcholine
(which is actually a very small blip of chemical that diffuses quite rapidly
across junctions of the nerve cell for stimulating the next cell), which is
utilized by nerve cells in brain part to think and for memory making. At the
same time, it is equally essential that acetylcholine gets eliminated at the
earliest after the message has been carried across junction. In case, it is
not, then it is likely to keep on stimulating downstream cell. It can be
disastrous, while leading to possible attacks.
Disturbance in Degradation
Process
Generally,
acetylcholine gets destroyed instantly after delivering the message by an
enzyme known as cholinesterase. In Alzheimer’s, nerve cell endings could get much
sicker and acetylcholine amount that is produced by every nerve impulse could
get lesser and lesser with the progress of the disease.
What does
Cholinesterase Inhibitors do?
Cholinesterase
inhibitors which are utilized as Alzheimer’s cure might restrain destroying by
cholinesterase of acetylcholine, which results in acetylcholine level getting
high enough for getting the message over the next cell.
Temporary Solution
However, this would not
work forever. Over a period of time, sick nerve endings tend to start
degenerating and withdrawing from junctions. The messages not longer could be
transferred. Generally, it takes around 2 to 3 years before the situation gets
reached (occasionally it tends to last much longer). It explains as to why cholinesterase
inhibitors generally work on a temporary basis.
Researching on Treatment
of the Disease
Scientists at Sarasota camp are continuing with the
research for coming up with treatments that are effective and for holding the
disease off, quickly. By researching on the web, one can get few examples. Article
regards to Nature Genetics does mention identification of more five genes
behind this disease by a research consortium.
The experts at Michael Mullan have been trying to come
up with researches for understanding the events which leads towards damage of
bigger brain parts and eventually complete loss of the cognitive abilities. According
to a published article in a leading Journal, insulin can have a new, powerful
role to fight the disease. The article describes new clinical researches done
by the experts that found that low insulin dose is found to suppress
successfully the expression in blood of 4 precursor proteins that are involve
in pathogenesis of the disease.
The roskamp institute states that it has been
working on to come up with novel cures having the capability to slow down the progression
rate of the disease and try to eradicate it in the near future.
